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. 2022 Sep 12;155:113666. doi: 10.1016/j.biopha.2022.113666

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Fig. 9 — Histopathological photomicrographs of H & E stained lung tissue sections of: Negative control showing normal alveolar spaces (A) with thin alveolar septa (thin arrow). Positive control with evident consolidation and cellular infiltration (thick arrow). The remnant alveoli depicted different features. Some were patent (A1) with thin (thin arrow) or thick (double arrow) alveolar septa. Others showed degeneration (A2). Intraluminal exudate and cellular debris are seen in the bronchiole (Br) and some alveoli (A3). Eosinophilic infiltration and exudate are occasionally seen (arrowhead). TSIIA suspension, NE-F8 and TSIIA-NE-F8 groups show improved lung condition, many alveoli are patent (A1) with thin alveolar septa (thin arrow) or slightly thickened ones (double arrow). Groups of narrow collapsed degenerated alveoli (A2) with intracellular debris are also seen. Notice the marked improvement in TSIIA-NE-F8 section. While in TSIIA suspension & NE-F8 groups, still there are widened consolidated areas (thick arrow) more prevalent in NE-F8 group. Both TSIIA suspension & NE-F8 groups also show peribronchiolar & localized cellular infiltration (I) surrounding an eosinophilic hyalinized materials that are also more evident in NE-F8 group. Scale bar represents 200 µm.