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. 2022 Aug 29;13:932596. doi: 10.3389/fphys.2022.932596

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Copyright © 2022 Li, Liu, Meng, Wu, Bing, Guo, Zhao, Hou, Wang, Xia and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Disrupted clock genes are risk factors for the presence of MetS components in OSA. Expression levels of the disrupted clock genes (Bmal1, Dec1, and Per1) in the peripheral blood mononuclear cells from the following indicated OSA subgroups: (A) fasting glucose<6.1 mmol/L vs. fasting glucose ≥6.1 mmol/L; (B) blood pressure <130/85 mmHg vs. blood pressure ≥130/85 mmHg; (C) triglycerides <1.7 mmol/L and HDL cholesterol ≥1.4 mmol/L vs. triglycerides ≥1.7 mmol/L or HDL cholesterol<1.4 mmol/L; (D) BMI <25, BMI ≥25; *, p < 0.05; **, p < 0.01; ***, p < 0.001.