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. 2022 Oct 1;13(5):1488–1503. doi: 10.14336/AD.2022.0218

Figure 4.

Figure 4.

UPP1 knockdown increases the antitumor effect induced by 2-DG. (A) UPP1 knockdown enhances the inhibitory effects of 2-DG on cell proliferation. (B-C) UPP1 knockdown reinforces the degree of apoptosis induced by 2-DG. (D-E) UPP1 knockdown significantly decreases OCR and ECAR levels compared to the 2-DG group. (F-G) UPP1 knockdown significantly reduces lactic acid production and glucose uptake in H1975 cells. (H) Expression of ENO1 and LDHA in UPP1 knockdown cells with 2-DG, as determined by western blot. One-way ANOVA (Fig. 4A, B, F, G). The experiments were independently conducted three times. **P<0.01, ***P<0.001 vs. shNC+vehicle. ###P<0.001 vs. shNC+2-DG.