Figure 6.

UPP1 significantly alters the sensitivity of tumors to glycolytic inhibitors in vivo. (A-D) 2-DG effectively suppresses subcutaneous tumor growth in nude mice (Vehicle group, n=3; 2-DG group, n=3). The tumor volumes in H1975+vehicle and H1975+2-DG, H1299+vehicle and H1299+2-DG in subcutaneous models are shown. (E-F) 2-DG effectively promotes apoptosis of tumor cells. H1299 cells with low UPP1 expression were more sensitive to 2-DG than H1975 cells with high UPP1 expression. One-way ANOVA in (Fig. 6A-B). Scale bar: 50 μm