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. 2022 Aug 30;14(16):6481–6506. doi: 10.18632/aging.204251

Figure 1.

Figure 1

Global bmm overexpression effectively promotes lipolysis in Drosophila. (A, B) Body weight of da-GAL4>UAS-bmm flies with ubiquitous bmm overexpression compared with control da-GAL4/+ flies. (C, D) TAG content in da-GAL4/+ and da-GAL4>UAS-bmm flies. (E, F) The survival curves of da-GAL4/+ vs. da-GAL4>UAS-bmm flies under starvation conditions fed on 1.5% w/v agar as a water source. n=100 for female group, n=60 for male group, and p value was determined by log-rank analysis. (G, H) TAG hydrolase activity of da-GAL4>UAS-bmm flies compared with control da-GAL4/+ flies. (I, J) TAG content in inducible da-GS-GAL4>UAS-bmm flies with or without 50 μM RU486 induction. n=6 replicates and each replicate contained 7-10 flies for (A–D, I, J); n=3 replicates and each replicate contained 20 flies for (G, H). Data are shown as mean±SEM and analyzed by two-tailed Student t-test. See also Supplementary Figure 1.