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. 2022 Sep 6;11(1):2111909. doi: 10.1080/2162402X.2022.2111909

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Figure 7. — Expedited growth of B16 melanomas in CD47-deficient mice is associated with decreased CD8+ effector T cells.

(a) B16F10 tumors were implanted in the hind limbs of WT and Cd47⁻^/- littermate mice (1 x 10⁶ cells/mouse). On day 15 after tumor implantation, mice were euthanized, and single-cell suspensions of spleens were stained for CD8+ T cells (values indicate percentage of CD3+ cells). (b) Representative contour plots (values indicate percentage of CD8+ cells) and frequency of CD44lo CD62L+ and CD44hi CD62L- CD8+ T cells within the spleens of mice on the 15th day post tumor implantation. (c) Frequency of PD1, CD39, TIGIT, CD127, and KLRG1-positive CD8+ T cells within the spleens of WT and Cd47⁻^/- (KO) mice on day 15 after tumor implantation. (d) Representative contour plots (values indicate percentage of CD3+ cells) and frequency of CD8+ T cells within the tumor of mice on the 15th day post tumor implantation. (e) Frequency of CD44hi and CD62L+ CD8+ T cells within the tumors of mice on the 15th day post tumor implantation. (f) Frequency of PD1, CD39, TIGIT, CD127, and GzmB-positive CD8+ T cells within the tumors of WT and Cd47⁻^/- (KO) mice on day 15 after tumor implantation. Representative of two independent experiments, n = 5 mice in each group.