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. 2022 Sep 8;60(1):1690–1700. doi: 10.1080/13880209.2022.2112239

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Kirenol inhibited the TGF-β/Smads signal pathway and attenuated ECM accumulation in the kidneys of diabetic mice. (A) The protein expression of FN, Col IV, Smad2/3 and p-Smad2/3 was detected by Western blot analysis. (B–D) Corresponding relative protein expression analysis of FN, Col IV and p-Smad2/3. (E) The protein expression of FN was detected by IHC. (C) The percentage of FN positive areas was determined using Image-J software. (G) Collagen fibres accumulation in the renal cortex was detected by Masson staining. Magnification: 400×, Scale bars: 50 μm. (H) The percentage of collagen fibre positive areas were determined by Image-J software. Data are expressed as mean ± SEM. *p < 0.05 vs. control group, #p < 0.05 vs. DM group.