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Kirenol could inhibit the NF-κB signal pathway and attenuate inflammation in the kidneys of diabetic mice. (A) The protein expression of IκBα, NF-κB and p-NF-κB was detected by Western blot analysis. (B, C) Corresponding relative protein expression analysis. The gene expression of IL-6 (D) and TNF-α (E) tested by RT-qPCR. Data are expressed as mean ± SEM. *p < 0.05 vs. control group, #p < 0.05 vs. DM group.
