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. 2022 Sep 10;14(1):2119055. doi: 10.1080/19490976.2022.2119055

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Immune regulation of gut microbiome are depended on the cGAS /STING signaling pathway in the HCC radiotherapy. GSEA analysis of Cytosolic DNA sensing pathway (p = .087, NES = 1.55). (b) Western blot analysis of STING, p-STING, p-p65, p-TBK1. Representative H22-OVA tumor growth curves of cGAS-/-(d) and STING-/- (c) mice during radiotherapy. Quantification of IFN-β mRNA by qRT-PCR in tumor draining lymph nodes of cGAS-/-(f) and STING-/- (e). Analysis of tumor-infiltrating CD8/IFN-γ + population (Live/CD45/CD3/CD8/IFN-γ cells) in cGAS-/-(h) and STING-/- (g) mice by flow cytometry. IFN-γ ELISPOT assay was performed in cGAS-/- (j) and STING-/- (i) mice. Representative data shown in B were conducted with 3 mice per group. Representative data shown in C to J were conducted with 5 mice per group. Data are represented as mean ± SEM. *P < .05, **P < .01, ***P < .001 and ns No significant difference.