Figure 4.

Knockdown of SAMHD1 accelerated the growth of subcutaneous transplantation tumors in nude mice. HGC-27 cells from shNC or shRNA-1 groups were injected subcutaneously into the middle-upper inguinal regions of the nude mice. (a) The mice with tumors were photographed under white light. (b) The tumors were resected from mice and photographed. (c) The body weight of mice in two groups. (d) The length and width of tumors were measured, and the tumor volume was calculated as: (length × width 2)/2. (e, f) Immunohistochemical staining of SAMHD1 protein in tumors and the staining score is presented. NS, no significance.