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. 2022 Jun 7;21(19):2065–2078. doi: 10.1080/15384101.2022.2085356

Figure 5.

Figure 5.

SAMHD1 inhibited the proliferation of gastric cancer cells via suppressing MAPK p38 signaling pathway. KEGG analysis of enriched signaling pathways in AGS cells (a) and HGC-27 cells (b) with different expression of SAMHD1. (c) Fifty-five common differently expressed genes are presented in heatmap. (d) The expression levels of MAP2K6 mRNA were detected. (e) The expression of MAP2K6 protein and phosphorylation levels of p38 at Thr180/Tyr182 were also detected. After treated with SB203580 for 48 h, the proliferation of HGC-27 cells (f) and the activation of MAPK p38 were assessed (g).