Table 1.
Summary of the ankyrin protein’s known channel and transporter interactions.
| Nervous system | Ankyrin | Transporter/Channel interaction(s) | Reference(s) |
|---|---|---|---|
| Inhibitory Neurons: Somatodendritic Domain | AnkR | Kv3.1b, Kv3.3 | [10,11] |
| Neurons: Neuromuscular Junction | AnkR | Nav1.4 | [9,95] |
| Neurons: Nodes of Ranvier (Secondary Composition) | AnkR | Nav, Kv3.1b, Kv3.3 | [8,10,61] |
| Neurons: Somatodendritic Domain | AnkB | Cav2.1, Cav2.2 | [45] |
| Neurons: Neuromuscular Junction | AnkB | Nav1.4 | [9,95] |
| Eye: Retina | AnkB | Na+/K+-ATPase†, NCX1† | [40] |
| Neurons: Axon Initial Segment | AnkG | Nav (Nav1.1, Nav1.2, Nav1.6), KCNQ2/3 | [8,19–21,49,96] |
| Neurons: Nodes of Ranvier (Primary Composition) | AnkG | Nav (Nav1.2, Nav1.6; also, Nav1.1, Nav1.8, Nav1.9), KCNQ2/3 | [8,17,19,21,51,58,59,97] |
| Neurons: Somatodendritic Domain | AnkG | AMPAR | [27] |
| Neurons: Neuromuscular Junction | AnkG | Nav1.4, KCNQ2 | [9,95] |
| Eye: Retina | AnkG | CNG I31 | [28] |
| Brain: Retina, etc. | Ank90 | AE3† | [34,35] |
| PERIPHERY | |||
| Blood: Erythrocyte | AnkR | Band3 (AE1), Rh, RhAG | [68,69,71,98–100] |
| Heart: Cardiomyocytes | AnkB | IP3R, Cav1.3, Kir6.2†,NCX, Na+/K+-ATPase, SERCA2, RyR† | [32,33,41,88,90,92,101–103] |
| Lymphocytes | AnkB | IP3R, RyR† | [37,89] |
| Heart: Cardiomyocytes | AnkG | Nav1.5, Kir6.1, Kir6.2 | [41,91,104] |
| Kidney, Lung: Epithelial Cells | AnkG | Na+/K+-ATPase, ENaC, RhBG†, kAE1† | [36,39,79,82,83,100,105] |
†Indicates that the interaction mechanism is not fully understood. For example, the interaction could be indirect, direct interaction has not been explicitly shown, the binding domain is unknown, or there is uncertainty about the ankyrin involved.