Table 4.
Correlation between COL10A1 and markers of immune cells in TIMER and GEPIA.
| Cell type | Gene marker | PAAD | |||
|---|---|---|---|---|---|
| None | Purity | ||||
| Cor | p | Cor | p | ||
| B cell | CD19 | 0.177 | 0.0176 | 0.126 | 0.096 |
| CD20 (krtx20) | 0.056 | 0.4 | 0.4 | 0.055 | |
| CD38 | 0.3 | ∗∗∗ | 0.26 | ∗∗ | |
| CD8+T cell | CD8A | 0.207 | ∗ | 0.152 | 0.0474 |
| CD8B | 0.187 | 0.0123 | 0.126 | 0.1 | |
| Tfh | CXCR5 | 0.059 | 0.444 | 0.119 | 0.114 |
| LCOS | 0.305 | ∗∗∗ | 0.266 | ∗∗∗ | |
| BCL-6 | 0.321 | ∗∗∗ | 0.3 | ∗∗∗ | |
| Th1 | IL-12RB2 | 0.023 | 0.756 | -0.007 | 0.931 |
| WSX-1 (IL-27RA) | 0.247 | ∗∗ | 0.204 | ∗ | |
| T-BET (TBX21) | 0.102 | 0.175 | 0.064 | 0.4 | |
| STAT1 | 0.476 | ∗∗∗ | 0.443 | ∗∗∗ | |
| IFN-γ (IFNG) | 0.258 | ∗∗ | 0.225 | ∗ | |
| TNF-α (TNF) | 0.279 | ∗∗ | 0.251 | ∗∗ | |
| Th2 | CCR3 | 0.368 | ∗∗∗ | 0.308 | ∗∗∗ |
| STAT6 | 0.178 | ∗ | 0.195 | ∗ | |
| GATA-3 | 0.289 | ∗∗ | 0.307 | ∗∗∗ | |
| STAT5A | 0.274 | ∗∗ | 0.236 | ∗ | |
| Th9 | TGF-BR2 | 0.43 | ∗∗∗ | 0.392 | ∗∗∗ |
| IRF4 | 0.257 | ∗∗ | 0.199 | ∗ | |
| PU.1 (SPI1) | 0.347 | ∗∗∗ | 0.313 | ∗∗∗ | |
| Th17 | IL-21R | 0.454 | ∗∗∗ | 0.494 | ∗∗∗ |
| IL-23R | 0.018 | 0.8 | 0.094 | 0.2 | |
| STAT3 | 0.431 | ∗∗∗ | 0.494 | ∗∗∗ | |
| Th22 | CCR10 | -0.035 | 0.639 | -0.041 | 0.597 |
| ARH | 0.454 | ∗∗∗ | 0.407 | ∗∗∗ | |
| Treg | FOXP3 | 0.445 | ∗∗∗ | 0.411 | ∗∗∗ |
| CCR8 | 0.527 | ∗∗∗ | 0.498 | ∗∗∗ | |
| CD25 (IL-2RA) | 0.445 | ∗∗∗ | 0.402 | ∗∗∗ | |
| T-cell exhaustion | PD-1 (PDCD1) | 0.116 | 0.122 | 0.048 | 0.531 |
| CTLA4 | 0.273 | ∗∗∗ | 0.222 | ∗ | |
| TIM-3 (HAVCR2) | 0.553 | ∗∗∗ | 0.514 | ∗∗∗ | |
| Macrophage | CD68 | 0.541 | ∗∗∗ | 0.499 | ∗∗∗ |
| CD11b (ITGAM) | 0.494 | ∗∗∗ | 0.437 | ∗∗∗ | |
| M1 | NOS2 | 0.278 | ∗∗∗ | 0.282 | ∗∗∗ |
| IRF5 | 0.213 | ∗ | 0.222 | ∗ | |
| M2 | ARG1 | -0.067 | 0.375 | 0.039 | 0.612 |
| MRC1 | 0.391 | ∗∗∗ | 0.395 | ∗∗∗ | |
| MS4A4A | 0.471 | ∗∗∗ | 0.42 | ∗∗∗ | |
| TAM | HLA-G | 0.111 | 0.137 | 0.063 | 0.413 |
| CD80 | 0.535 | ∗∗∗ | 0.514 | ∗∗∗ | |
| CD86 | 0.525 | ∗∗∗ | 0.489 | ∗∗∗ | |
| CCR5 | 0.338 | ∗∗∗ | 0.278 | ∗ | |
| Monocyte | CD14 | 0.363 | ∗∗∗ | 0.307 | ∗∗∗ |
| CD16 (FCGR3B) | 0.384 | ∗∗∗ | 0.326 | ∗∗∗ | |
| CD115 (CSF1R) | 0.411 | ∗∗∗ | 0.349 | ∗∗∗ | |
| NK | XCL1 | 0.127 | 0.0899 | 0.098 | 0.2 |
| KIR3DL1 | 0.093 | 0.216 | 0.07 | 0.363 | |
| CD7 | 0.115 | 0.125 | 0.061 | 0.425 | |
| Neutrophil | CD15 (FUT4) | 0.24 | ∗ | 0.183 | 0.164 |
| MPO | 0.318 | ∗∗∗ | 0.327 | ∗∗ | |
| CD11b (ITGAM) | 0.494 | ∗∗∗ | 0.437 | ∗∗∗ | |
| DC | CD1C (BDCA-1) | 0.187 | 0.0124 | 0.148 | 0.0528 |
| CD141 | 0.232 | ∗ | 0.228 | ∗ | |
| CD11c (ITGAX) | 0.452 | ∗∗∗ | 0.403 | ∗∗∗ | |
Tfh, follicular helper T cell; Th, T helper cell; Treg, regulatory T cell; TAM, tumor-associated macrophage; none, correlation without adjustment; purity, correlation adjusted by purity; Cor, R value of Spearman's correlation. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001.