TABLE 6.
Cases With Histologic Follow-Up and Correlation With Indeterminate Cytology
| Variable | FN (n = 34) | FLUS (n = 35) | OR | P |
|---|---|---|---|---|
| Age, range, y | 17–79 | 20–74 | — | — |
| Sex, No. | — | — | ||
| Female | 30 | 26 | ||
| Male | 4 | 9 | ||
| Molecular alterations, No. | ||||
| RAS alone | 13 | 23 | 0.33 | .02 |
| RAS with others | 21 | 12 | ||
| Procedure, No. | ||||
| Lobectomy | 15 | 22 | 0.47 | .09 |
| Total | 19 | 13 | ||
| Histology, No. | ||||
| Nonneoplastic | 14 | 19 | 0.3 | .025a |
| Neoplastic | 6 | 10 | ||
| Malignant | 14 | 6 | ||
| Molecular alteration and histology correlation, No. | ||||
| RAS alone + negative histology | 11 | 19 | 1.15 | .72 |
| RAS alone + positive histology | 2 | 4 | ||
| RAS and others + negative histology | 9 | 10 | 0.159 | .03 |
| RAS and others + positive histology | 12 | 2 | ||
| Risk of malignancy, % | ||||
| RAS alone | 15 | 17 | 0.27 | .003 |
| RAS with others | 57 | 17 | ||
| RAS (overall) | 38 | 17 |
Abbreviations: FLUS, follicular lesion of undetermined significance; FN, follicular neoplasm; OR, odds ratio.
a
Nonneoplastic + neoplastic versus malignant = P value.