Table 3:
Pharmacokinetic data for carboplatin given as mean (95% confidence interval) for all compartments.
| Compartment | n | AUC0-last (min·µg/mL) | Cmax (µg/mL) | Tmax (min) |
|---|---|---|---|---|
| Liver | 8 | 3,469 (2,122; 4,816) | 13.0 (4.6; 21.3) | 206 (124; 289) |
| HL superficial | 8 | 3,557 (2,210; 4,904) | 15.4 (7.1; 23.8) | 186 (103; 268) |
| HL profound | 8 | 3,299 (1952; 4,646) | 12.6 (4.3; 21.0) | 178 (96; 261) |
| Peritoneum | 7 | 4,561 (3,171; 5,951) | 26.0 (17.2; 34.7) | 196 (109; 283) |
| Rectum superficial | 6 | 3,639 (2,192; 5,086) | 15.1 (5.8; 24.3) | 175 (81; 268) |
| Rectum profound | 5 | 4,207 (2,683; 5,732) | 20.6 (10.7; 30.5) | 205 (103; 307) |
| Mesentery | 8 | 3,300 (1953; 4,647) | 12.4 (4.1; 20.8) | 197 (114; 279) |
| Bladder wall | 3 | 5,176 (3,367; 6,985) | 22.0 (9.7; 34.2) | 197 (69; 326) |
| Plasma | 8 | 2,657 (1,310; 4,004) | 10.6 (2.2; 19.0) | 105 (23; 187) |
AUC0-last, area under the curve from 0 to time for last sample collection; Cmax, peak drug concentration; Tmax, time to peak drug concentration; HL, hepatoduodenal ligament; n, number of animals from which samples were collected.