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Piperine altered gut microbiota profiles in high-fat diet-fed mice. (A) The OTUs distribution among different groups shown as Venn diagram. (B) Chao1 richness of gut microbiota. (C) Species rank abundance curves. (D) PCoA plot of microbial communities based on the weighted UniFrac distances. Mean ± SD (n = 6); *p < 0.05 vesus Model. PIP 20 (piperine at 20 mg/kg). PIP 40 (piperine at 40 mg/kg).
