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. 2022 Sep 12;12:15299. doi: 10.1038/s41598-022-17808-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Evolution of the cognitive composite score (Z-Score) in the groups with participants not treated (PNT) with urate-lowering therapies (ULT), participants treated with ULT less than 75% of the study follow-up (PT < 75) and participants treated with ULT more than 75% of the study follow-up (PT ≥ 75) during a 5-year follow-up, among the participants of the MAPT study. PNT: patients not treated with urate-lowering therapies. PT < 75 : participants treated with urate-lowering therapies less than 75% of the study follow-up. PT ≥ 75 : participants treated with urate-lowering therapies more than 75% of the study follow-up.