Table 2.
Linear mixed models presenting changes of the composite cognitive score according to urate-lowering therapies administration among community-dwelling older adults.
| Time | Estimated change from baseline | Estimated differences in change from baseline | Estimated differences in change from baseline | ||||
|---|---|---|---|---|---|---|---|
| PNT mean [95%CI] p-value | PT < 75% mean [95%CI] p-value | PT ≥ 75% mean [95%CI] p-value | PT < 75% vs PNT mean [95%CI] p-value | PT ≥ 75% vs PNT mean [95%CI] p-value | PT < 75% vs PNT mean [95%CI] p-value | PT ≥ 75% vs PNT mean [95%CI] p-value | |
| Not adjusted | Adjusted(1) | ||||||
| 3 years |
− 0.060 [− 0.090 to − 0.029] p = 0.0002 |
− 0.049 [− 0.251 to 0.153] p = 0.633 |
0.055 [− 0.115 to 0.224] p = 0.528 |
0.010 [− 0.194 to 0.214] p = 0.920 |
0.114 [− 0.058 to 0.286] p = 0.194 |
0.061 [− 0.140 to 0.263] p = 0.551 |
0.162 [− 0.011 to 0.335] p = 0.066 |
| 5 years |
− 0.173 [− 0.212 to − 0.135] p < 0.0001 |
− 0.155 [− 0.405 to 0.095] p = 0.223 |
− 0.088 [− 0.300 to 0.124] p = 0.414 |
0.018 [− 0.235 to 0.271] p = 0.889 |
0.085 [− 0.130 to 0.300] p = 0.437 |
0.103 [− 0.148 to 0.353] p = 0.421 |
0.144 [− 0.075 to 0.363] p = 0.196 |
PNT: participants not treated; PT < 75: participants treated less than 75% of the study follow-up; PT ≥ 75: participants treated more than 75% of the study follow-up.
(1)Adjustment for age, sex, body mass index (BMI), arterial hypertension, diabetes, allocation to MAPT intervention groups, baseline composite cognitive score and their interactions with time.