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. 2022 Aug 18;144(4):785–787. doi: 10.1007/s00401-022-02481-w

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — t-SNE plot of DNA methylation profiles in including training (transparent) and test (opaque) appendix samples. Five plots show the same sample locations with various overlay colours including diagnosis, sample plate, sex, age, and tissue processing status. Test samples are shown in opaque colour on top of discovery/training samples in transparent colours. Total sample size n = 219. PrP-pos refers to Appendix II or III samples that showed abnormal PrP immunohistochemistry