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. 2022 Sep 12;13:5338. doi: 10.1038/s41467-022-33006-4

Fig. 7. S3-15 has no adverse effects on T lymphocyte differentiation.

Fig. 7

a CD4+ T cell differentiation ratio in gate of CFSE− cells in T cell sample of healthy donors 1. T cells of healthy donors 1 were induced by anti-CD3 antibody (5 μg/mL) and anti-CD28 antibody (5 μg/mL) for 3 days or 12 days with/without treatment. b CD4+ T cell differentiation ratio in gate of total cells and gate of CFSE− cells in T cell sample of healthy donors 2. T cells of healthy donors 2 were induced by anti-CD3 antibody (5 μg/mL) and anti-CD28 antibody (5 μg/mL) for 9 days with or without treatment. c CD4+ T cell differentiation ratio in gate of total cells and gate of CFSE− cells in T cell sample of cancer patient donors 1. T cells of cancer patient donors 1 were induced by anti-CD3 antibody (5 μg/mL) and anti-CD28 antibody (5 μg/mL) for 3 days with or without treatment. In experiments of a–c, CFSE− cells, CD4+ cells, CD8+ cells were assayed by flow cytometry and analyzed their percentage in the corresponding gate after treatment. Data are presented as the mean ± s.d. from three or four biological replicate per group. Statistical difference was determined by unpaired two-tailed Student’s t-test. Significant difference p-value is < 0.05.