Fig. 1.

A model for the influence of IDH mutations on glioma cells and their surrounding immune microenvironment. In glioma cells, IDH mutations regulate gene expression via three mechanisms: transcriptional (via inhibition of DNA and histone demethylases), post-transcriptional (via inhibition of m6A demethylases), and post-translational (via inhibition of EGLN) modifications. In addition, IDH mutations affect the immune microenvironment of gliomas, modifying immune cell infiltration and functioning in direct (via regulating immune-related gene expression) and indirect ways (via IDH mutation-derived D2-HG).