Table 1.
Characteristics | Age at diagnosis, ya |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
60-64 |
65-69 |
70-74 |
75-79b |
Total |
||||||
Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | |
Total No. | 4263 | 8477 | 4785 | 9504 | 4639 | 9179 | 949 | 1876 | 14636 | 29036 |
Stage at diagnosis, % | ||||||||||
Stage A | 15.9 | 14.2 | 14.2 | 12.4 | 14.6 | |||||
Stage B | 20.9 | 23.7 | 24.1 | 22.9 | 22.9 | |||||
Stage C | 27.5 | 25.0 | 23.4 | 23.2 | 25.1 | |||||
Stage D | 13.0 | 13.0 | 11.6 | 10.9 | 12.4 | |||||
Missing stage, % | ||||||||||
Suspected Duke Dc | 7.1 | 9.7 | 13.0 | 16.3 | 7.3 | |||||
Stage B or worse NOSd | 7.0 | 7.1 | 7.2 | 9.7 | 10.4 | |||||
Stage unknown | 8.6 | 7.3 | 6.5 | 4.6 | 7.3 | |||||
Gender, % | ||||||||||
Male | 58.9 | 56.8 | 56.2 | 51.3 | 56.9 | |||||
Female | 41.1 | 43.2 | 43.8 | 48.7 | 43.1 | |||||
Screening exposure, % | ||||||||||
Invited but not screenede | 40.3 | 45.9 | 38.4 | 36.2 | 40.5 | 39.3 | 49.5 | 40.2 | 40.3 | 40.3 |
Screened | 59.7 | 54.1 | 61.6 | 63.8 | 59.5 | 60.7 | 50.5 | 59.8 | 59.7 | 59.7 |
Time since last screen, % | ||||||||||
<1 y | 40.3 | 28.4 | 34.8 | 28.3 | 27.7 | 21.7 | 1.7 | 3.8 | 32.0 | 24.7 |
>1 y to 2 y | 14.4 | 18.7 | 18.2 | 24.4 | 11.6 | 15.1 | 19.5 | 25.9 | 15.1 | 19.9 |
>2 y to 3 y | 3.7 | 5.7 | 5.2 | 7.0 | 7.1 | 8.9 | 16.2 | 17.4 | 6.1 | 7.8 |
>3 y to 4 y | 1.1 | 1.1 | 2.1 | 2.3 | 6.8 | 7.2 | 5.7 | 6.6 | 3.5 | 3.8 |
>4 y | 0.2 | 0.5 | 1.3 | 1.9 | 6.3 | 7.8 | 7.4 | 6.1 | 3.0 | 3.6 |
Note that prior to excluding cases who were not invited for screening, 47.5% of all cancers were diagnosed at ages 60-69 years. A larger proportion of cases were excluded at ages 70-79 years because they had not been invited prior to diagnosis. B+ NOS = Duke B or worse not otherwise specified.
Three controls opted into screening.
All individuals died within 1 year of diagnosis and hence are suspected to be Duke D.
Survival and other tumor characteristics suggest stage B+ NOS.
Excludes those whose only test was within 7 days of diagnosis or who only had tests at younger than 60 years.