Table 2.
Risk factors for need for respiratory support in RSV positive hospitalized children under 5 years of age.
| Complete case analysis a | Multiple imputation b | |||
|---|---|---|---|---|
| Risk factor | Adjusted OR (95% CI) | p-valuec | Adjusted OR (95% CI) | p-valuec |
| Demographic | ||||
| Age by age group | ||||
| <3 m | 12.5 (2.11–73.8) | 0.005 | 6.73 (2.71–16.7) | <0.001 |
| 3–5 m | 3.97 (0.65–24.30) | 0.136 | 2.00 (0.77–5.17) | 0.155 |
| 6–11 m | 1.69 (0.27–10.76) | 0.579 | 1.22 (0.48–3.09) | 0.670 |
| 12–23 m | 3.49 (0.61–19.77) | 0.158 | 1.23 (0.64–2.37) | 0.536 |
| 24–59 m | Ref | Ref | ||
| Sex, female | 0.84 (0.51–1.38) | 0.485 | 0.79 (0.57–1.10) | 0.165 |
| Siblings | 2.66 (1.32–5.33) | 0.006 | 1.65 (1.05–2.59) | 0.029 |
| Pets at home | 1.66 (0.98–2.80) | 0.057 | 1.15 (0.78–1.68) | 0.480 |
| Day-care attendance | 0.98 (0.37 to2.58) | 0.964 | 1.21 (0.60–2.42) | 0.596 |
| Gestational | ||||
| Maternal age, per year | 1.02 (0.97–1.07) | 0.435 | 0.98 (0.95–1.02) | 0.284 |
| Smoking during pregnancy | 0.15 (0.02–1.31) | 0.086 | 0.42 (0.12–1.46) | 0.170 |
| GA <32 weeks | 1.38 (0.21–8.91) | 0.733 | 1.42 (0.50–4.01) | 0.508 |
| Cesarean delivery | 1.78 (0.96–3.31) | 0.066 | 1.11 (0.72–1.68) | 0.643 |
| Multiple gestation | 0.83 (0.22–3.15) | 0.779 | 1.16 (0.56–2.39) | 0.696 |
| Small for gestational age | 1.01 (0.42–2.42) | 0.981 | 0.97 (0.52–1.83) | 0.935 |
| Comorbidity and dispositions | ||||
| No breastfeeding | 1.65 (0.65–4.17) | 0.295 | 1.57 (0.73–3.42) | 0.250 |
| Family history of atopy | 1.55 (0.75–3.19) | 0.237 | 1.62 (0.98–2.66) | 0.060 |
| Comorbidityd | 3.19 (1.19–8.52) | 0.021 | 2.40 (1.35–4.24) | 0.003 |
| Respiratory disease during infancy | 1.88 (0.53–6.69) | 0.329 | 1.39 (0.69–2.78) | 0.355 |
| Viral Co-detection | 1.32 (0.49–3.51) | 0.581 | 1.32 (0.71–2.49) | 0.382 |
aMultivariate logistic regression analysis including all co-variates listed in the table. A total of 399 cases had complete data in all covariates. bMultiple logistic regression analysis after multiple imputation of missing data. Analysis includes all 1096 RSV cases. cResults significant at a level of 0.05 in bold text. A total of 16 associations are explored in this table, a Bonferroni-correction for test multiplicity suggests a level of significance at 0.05/16 = 0.003. dComorbidity includes congenital heart disease, neuromuscular impairment, Trisomy 21, bronchopulmonary dysplasia, chronic respiratory disease excluding asthma, immunodeficiency including children receiving chemotherapy for cancer.