Table 4.
Risk factors for length of stay over 72 h in RSV positive children under 5 years of age.
| Complete case analysis a | Multiple imputation b | |||
|---|---|---|---|---|
| Risk factor | Adjusted OR (95% CI) | p-valuec | Adjusted OR (95% CI) | p-valuec |
| Demographic | ||||
| Age by age group | ||||
| <3 m | 5.92 (1.27–27.7) | 0.024 | 3.52 (1.65–7.54) | 0.001 |
| 3–5 m | 2.02 (0.41–9.90) | 0.386 | 1.08 (0.49–2.40) | 0.841 |
| 6–11 m | 1.20 (0.25–5.89) | 0.819 | 1.11 (0.53–2.32) | 0.789 |
| 12–23 m | 3.09 (0.74–12.93) | 0.122 | 1.55 (0.94–2.56) | 0.085 |
| 24–59 m | Ref | |||
| Sex, female | 0.91 (0.58–1.44) | 0.699 | 0.96 (0.72–1.27) | 0.773 |
| Siblings | 1.53 (0.87–2.69) | 0.141 | 1.45 (1.01–2.08) | 0.043 |
| Pets at home | 1.49 (0.92–2.40) | 0.107 | 1.10 (0.79–1.52) | 0.582 |
| Day-care attendance | 1.00 (0.42 to2.38) | 0.996 | 1.08 (0.60 to1.95) | 0.795 |
| Gestational | ||||
| Maternal age, per year | 1.02 (0.97–1.06) | 0.516 | 1.00 (0.97–1.03) | 0.783 |
| Smoking during pregnancy | 0.34 (0.08–1.33) | 0.120 | 0.56 (0.23–1.39) | 0.213 |
| GA <32 weeks | 0.66 (0.11–3.88) | 0.650 | 1.43 (0.55–3.74) | 0.465 |
| Cesarean delivery | 1.18 (0.66–2.12) | 0.569 | 1.36 (0.95–1.94) | 0.096 |
| Multiple gestation | 0.82 (0.24–2.80) | 0.752 | 1.08 (0.58–2.02) | 0.813 |
| Small for gestational age | 1.43 (0.66–3.10) | 0.371 | 1.01 (0.60–1.70) | 0.967 |
| Comorbidity and dispositions | ||||
| No breastfeeding | 1.01 (0.42–2.43) | 0.987 | 1.07 (0.54–2.14) | 0.841 |
| Family history of atopy | 2.15 (1.12–4.11) | 0.021 | 1.34 (0.87–2.07) | 0.188 |
| Comorbidityd | 2.21 (0.89–5.47) | 0.086 | 2.18 (1.31–3.61) | 0.003 |
| Respiratory disease during infancy | 1.61 (0.51–5.10) | 0.417 | 1.00 (0.54–1.85) | 0.994 |
| Viral Co-detection | 1.71 (0.69–4.22) | 0.245 | 1.48 (0.86–2.53) | 0.153 |
aMultivariate logistic regression analysis including all co-variates listed in the table. A total of 399 cases had complete data in all covariates. bMultiple logistic regression analysis after multiple imputation of missing data. Analysis includes all 1096 RSV cases. cResults significant at a level of 0.05 in bold text. A total of 16 associations are explored in this table, a Bonferroni-correction for test multiplicity suggests a level of significance at 0.05/16 = 0.003. dComorbidity includes congenital heart disease, neuromuscular impairment, trisomy 21, bronchopulmonary dysplasia, chronic respiratory disease excluding asthma, immunodeficiency including children receiving chemotherapy for cancer.