Capsaicin regulates proteins associated with oxidative stress and endothelial dysfunction in vivo. (A–G) Shown is the expression of TRPV1, poldip2, Nox4, VCAM-1, HIF-1α, and VEGF in rat retina in different groups. (H–I) The expression of TRPV1, poldip2, and Nox4 in rat retina by immunofluorescence in different groups. One-way ANOVA data represents mean ± SEM, n = 3–5/group, Scale bar: 50 μm. Compared with NC group: *p < 0.05, **p < 0.01; Compared with DM group: #p < 0.05, ##p < 0.01. NC: normal control group. DM: diabetic group. DM + CAP: diabetic with capsaicin treatment group.