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. 2022 Sep 3;56:102460. doi: 10.1016/j.redox.2022.102460

Fig. 6.

Fig. 6

Capsaicin inhibits poldip2-mediated oxidative stress by inhibiting PPARγ. (A–C) The levels of PPARγ, p-PPARγ, u-PPARγ and poldip2 in rat retina are shown in different groups. One-way ANOVA. (D–J) Displayed is the expression of poldip2, Nox4, VCAM-1, HIF-1α and VEGF in cultured HRMECs treated by NC-siRNA and PPARγ siRNA, respectively. Student's t-test. (K–M) Levels of ROS and H2O2 in cultured HRMECs treated by NC-siRNA and PPARγ siRNA, respectively. Student's t-test. Data represents mean ± SEM, n = 3/group, scale bar: 50 μm. Compared with NG group: *p < 0.05, **p < 0.01; compared with HG group: #p < 0.05. Compared with si-NC group: *p < 0.05. **p < 0.01. NG: normal glucose group, HG: high glucose group, HG + CAP: high glucose with capsaicin treatment group. si-NC: control group, si- PPARγ: PPARγ siRNA transfection group.