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. 2022 Sep 3;56:102460. doi: 10.1016/j.redox.2022.102460

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© 2022 The Authors. Published by Elsevier B.V.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 9 — Knockdown of poldip2 in vivo regulates proteins associated with oxidative stress and endothelial dysfunction. (A–C) The expression of GFP, poldip2, Nox4, VCAM-1, HIF-1α and VEGF in rat retina is shown in different groups with/without poldip2-shRNA treatment. (D–F) The expression of poldip2 and Nox4 in rat retina detected by immunofluorescence in different groups with/without poldip2-shRNA treatment. One-way ANOVA. Data are the means ± SEM from 5/group (A) and 3/group (D). Compared with NC group: *p < 0.01, **p < 0.01; Compared with DM + NC-shRNA group: ^##p < 0.01. NC: normal control group. DM + NC-shRNA group: diabetic group treated with scrambled-AAV9-shRNA. DM + poldip2-shRNA: diabetic treated with AAV₉-poldip2-shRNA.