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. 2022 Jun 22;15(9):2135–2145. doi: 10.1111/cts.13347

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© 2022 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Sertraline serum concentration measurements in patient subgroups carrying different CYP2C19 genotypes in combination with CYP2C:TG, where the crossbar indicates the predicted mean serum concentration for each diplotype. Sertraline serum concentrations were normalized to the dosage of 100 mg/day. The predicted mean serum concentration is based on mixed‐model analyses of the different CYP2C19 genotypes and is presented as crossbar for each CYP2C19 diplotype. Patients with a CYP2C19*1/*1 genotype were used as reference in the mixed‐model analysis. Null = no function allele (i.e., presence of CYP2C19*2, CYP2C19*3, or CYP2C19*4). The dotted line indicates the therapeutic reference range (30–250 nM)