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. 2022 Aug 30;13:940406. doi: 10.3389/fphar.2022.940406

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Copyright © 2022 Xu, Liu, Li, Xiao, Gao, Zhang, Lu, Wang, Guo, Wen and Gu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Resveratrol (RES) and fibroblast growth factor 1 (FGF1) co-treatment alleviated liver damage, inflammation, and hepatocyte apoptosis in doxorubicin (DOX)-treated mice. (A) Effects of RES and/or FGF1 on the liver index in mice with DOX-induced liver damage (n = 6). (B,C) Serum levels of ALT and AST after the indicated treatments (n = 6). (D) Representative light microscopy images showing histopathological changes in liver tissues stained with H&E staining. (E,F) Representative microscopy images showing IHC staining of TNF-α in liver tissues (n = 6). (G–I) Relative mRNA expression levels of Tnfa, Il1b, and Il6 in hepatocytes (n = 6). (J) Representative fluorescence microscopy images of apoptotic hepatocytes labeled by TUNEL staining. Data are expressed as mean ± SD. *p < 0.05.