TABLE 2.

List of genes and mutant phenotypes related to fetal nuchal edema with cardiac anomalies in mice (loss-of-function mutations).

Gene	Mutant phenotype	References
Gata4; Gata6	VSD; PTA; thin ventricular myocardium	Xin et al., 2006
	Congenital heart diseases (human)
Tbx1	VSD; PTA	Vitelli et al., 2002; Burger et al., 2016
	Congenital heart diseases (human)
Dock1	VSD; DORV	Sanematsu et al., 2010
Adm	Small ventricular chamber size; thin and convoluted ventricular myocardium	Caron and Smithies, 2001
Calcrl	Small heart; thin and convoluted ventricular myocardium	Dackor et al., 2006
Nfat5	Thin ventricular myocardium	Mak et al., 2011
Chd7	VSD	Bosman et al., 2005
	CHARGE syndrome (human)
Crk	VSD; DORV; thin ventricular myocardium and interventricular septum; dilated ventricular chamber	Park et al., 2006; Imamoto et al., 2020
Fkbp1a	VSD; enlarged heart; thin ventricular myocardium	Shou et al., 1998
Myh10	VSD; DORV	Ma and Adelstein, 2014
Ngly1	VSD	Fujihira et al., 2017
Sp3	AVSD; DORV; thin ventricular myocardium	van Loo et al., 2007
Strn3	VSD	Dickinson et al., 2016

AVSD, atrioventricular septal defect; DORV, double outlet right ventricle; PTA, persistent truncus arteriosus; VSD, ventricular septal defect.