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. 2022 Aug 30;16:938403. doi: 10.3389/fnbeh.2022.938403

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Copyright © 2022 Geurts, Van den Heuvel, Huys, Verkes and Cools.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Association between amygdala BOLD signal change and symptom improvement. Pre-treatment PIT-related BOLD signal in the left amygdala predicts symptom improvement 1 year later. Images are displayed at a statistical threshold of p < 0.001 uncorrected. The scatter plot shows the PIT-related beta estimate contrast for aversive minus neutral CS trials before treatment in relation to symptom improvement, derived from a leave-one-participant-out cross-validation procedure. The regression line is the ordinary least square line. The gray area depicts the reliable change index (RCI) range; the changes outside this area are regarded as reliable (based on Jacobson and Truax, 1991).