Table 2.
Patient toxicities by erlotinib dose.
| Dose = 150 (N = 11) | Dose = 300 (N = 12) | ||||
|---|---|---|---|---|---|
| Complication | Grade | n | % | n | % |
| Rash | 1 | 3 | 27.3 | 6 | 50.0 |
| 2 | 5 | 45.5 | 5 | 41.7 | |
| 3 | 0 | 0.0 | 1 | 8.3 | |
| Diarrhea | 1 | 3 | 27.3 | 5 | 41.7 |
| 2 | 1 | 9.1 | 0 | 0.0 | |
| Nausea | 1 | 4 | 36.4 | 3 | 25.0 |
| Mucositis | 2 | 2 | 18.2 | 0 | 0.0 |
| 3 | 1 | 9.1 | 0 | 0.0 | |
| Dry eyes | 1 | 2 | 18.2 | 0 | 0.0 |
| Loss of appetite | 1 | 0 | 0.0 | 2 | 16.7 |
| Elevated bilirubin | 1 | 3 | 27.3 | 2 | 16.7 |
| 2 | 3 | 27.3 | 2 | 16.7 | |
| Elevated GGT | 1 | 2 | 18.2 | 1 | 8.3 |
| Elevated Alkaline Phosphatase | 1 | 0 | 0.0 | 1 | 8.3 |
| Elevated SGOT | 1 | 0 | 0.0 | 4 | 33.3 |
| Elevated SGPT | 1 | 0 | 0.0 | 2 | 16.7 |
| 2 | 0 | 0.0 | 1 | 8.3 | |
| Decreased Mg | 1 | 4 | 36.4 | 9 | 75 |