Figure 3.

TIGIT⁺ PD-1⁺ CXCR5^- CD4⁺ T and TIGIT^- PD-1⁺ CXCR5^- CD4⁺ T cell levels are correlated with those of anti-CCP and RF in patients with RA. The percentage of TIGIT⁺ PD-1⁺ CXCR5^- CD4⁺ T cells was positively correlated with (A) anti-CCP, (B) increased anti-CCP (anti-CCP>25 RU/ml) and (C) increased RF (RF>20 IU/ml). The correlation between (D) MFI of PD-1 in TIGIT⁺ PD-1⁺ CXCR5^- CD4⁺ T cells, (E) Percentage of TIGIT^- PD-1⁺ CXCR5^- CD4⁺ T cells, (F) MFI of PD-1 in TIGIT^- PD-1⁺ CXCR5^- CD4⁺ T cells and increased RF (RF>20 IU/ml). Anti-CCP, anti-cyclic citrullinated peptide antibodies; MFI, mean fluorescence intensity; PD-1, programmed cell death protein 1; RA, rheumatoid arthritis; RF, rheumatoid factor; TIGIT, T cell immunoreceptor with immunoglobulin and ITIM domain; CXCR5, C-X-C chemokine receptor type 5.