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. 2022 Aug 30;12:967436. doi: 10.3389/fonc.2022.967436

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Copyright © 2022 Li, Chen, Yang, Zhu, Yang, Li and Fu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Illustration of the KDE method in the brachytherapy treatment planning. For each voxel in the OAR, xi is the distance between this voxel and its closest voxel on the HRCTV surface and di is the dose received in each voxel inside the OAR.