Table 2.

Detailed results of receiver operating characteristic curve analyses for predictors of early neurological deterioration

	AUC (95% CI)	Optimal cut-off	Sensitivity (95% CI)	Specificity (95% CI)	PPV (95% CI)	NPV (95% CI)
UWDRS part III	0.803 (0.669–0.916)	17.50	0.700 (0.400–1.000)	0.823 (0.706–0.922)	0.434 (0.266–0.643)	0.935 (0.872–1.000)
UWDRS part II	0.715 (0.530–0.879)	1.50	0.600 (0.300–0.900)	0.804 (0.686–0.902)	0.338 (0.200–0.583)	0.913 (0.848–0.976)
MRI: acute toxicity	0.682 (0.514–0.849)	1.50	0.700 (0.400–1.000)	0.725 (0.588–0.843)	0.333 (0.200–0.500)	0.927 (0.857–1.000)
MRI: chronic damage	0.774 (0.623–0.901)	1.50	0.900 (0.700–1.000)	0.647 (0.509–0.764)	0.333 (0.250–0.435)	0.971 (0.912–1.000)
MRI: total score	0.731 (0.563–0.869)	1.50	0.900(0.700–1.000)	0.608 (0.471–0.745)	0.310 (0.233–0.409)	0.970 (0.903–1.000)
sNfL	0.770 (0.622–0.896)	18.15	0.800 (0.500–1.000)	0.725 (0.588–0.843)	0.363 (0.250–0.5000	0.950 (0.881–1.000)

AUC area under the curve, CI confidence interval, MRI magnetic resonance imaging, NPV negative predictive value, PPV positive predictive value, SD standard deviation, sNfL serum neuro-filament light chain, UWDRS Unified Wilson’s Disease Rating Scale