Table 3.
Univariate logistic regressions predicting neurological deterioration amongst all patients and those with neurological symptoms only
| Predictor | All patients (n = 61) | Patients with neurological symptoms (n = 36) | ||
|---|---|---|---|---|
| OR (95% CI) | P value* | OR (95% CI) | P value* | |
| d-penicillamine vs zinc sulphate | 1.98 (0.49–1.87) | 0.333 | 1.27 (0.29–5.66) | 0.740 |
| UWDRS Part II (above vs below cut-off) | 6.15 (1.46–26.00) | 0.014 | 2.40 (0.5–10.6) | 0.250 |
| UWDRS Part III (above vs below cut-off) | 10.89 (2.35–50.40) | 0.002 | 4.40 (0.9–21.3) | 0.065 |
| MRI: acute toxicity (above vs below cut-off) | 6.17 (1.40–27.25) | 0.016 | 2.00 (0.4–9.4) | 0.383 |
| MRI: chronic damage (above vs. below cut-off) | 16.50 (1.93–140.85) | 0.010 | 5.62 (0.6–51.3) | 0.616 |
| MRI: total score (above vs. below cut-off) | 13.95 (1.64–118.70) | 0.016 | 4.00 (0.4–37.1) | 0.431 |
| sNfL (above vs. below cut-off) | 10.57 (2.00–55.99) | 0.006 | 6.40 (1.12–36.43) | 0.036 |
Cut-off values for individual predictors were taken from receiver operating characteristic curve analyses
CI confidence interval, MRI magnetic resonance imaging, OR odds ratio, sNfL serum neuro-filament light chain, UWDRS Unified Wilson’s Disease Rating Scale
*Wald test