Table 4.
Bivariate logistic regression models predicting neurological deterioration amongst all patients
| Predictor (above vs below cut-off) | OR (95% CI) | P value* | |
|---|---|---|---|
| Model 1 | sNfL | 6.94 (1.19–40.47) | 0.031 |
| UWDRS part III | 7.14 (1.40–36.49) | 0.018 | |
| Model 2 | MRI: acute toxicity | 1.63 (0.20–13.30) | 0.649 |
| UWDRS part III | 7.76 (0.97–62.14) | 0.054 | |
| Model 3 | MRI: chronic damage | 7.58 (0.69–83.10) | 0.097 |
| UWDRS part III | 4.01 (0.70–22.92) | 0.118 | |
| Model 4 | MRI: total score | 5.64 (0.46–68.46) | 0.175 |
| UWDRS part III | 4.28 (0.71–25.92) | 0.114 | |
| Model 5 | MRI: acute toxicity | 3.88 (0.79–19.09) | 0.095 |
| sNfL | 7.64 (1.37–42.82) | 0.021 | |
| Model 6 | MRI: chronic damage | 10.32 (1.13–94.24) | 0.039 |
| sNfL | 6.31 (1.09–36.63) | 0.040 | |
| Model 7 | MRI: total score | 8.22 (0.89–75.57) | 0.063 |
| sNfL | 6.30 (1.10–36.16) | 0.039 |
Cut-off values for individual predictors were taken from receiver operating characteristic curve analyses
CI confidence interval, MRI magnetic resonance imaging, OR odds ratio, sNfL serum neuro-filament light chain, UWDRS Unified Wilson’s Disease Rating Scale
*Wald test