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. 2022 Aug 29;13:988083. doi: 10.3389/fmicb.2022.988083

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Copyright © 2022 Lootens, De Boevre, Gasthuys, Van Bocxlaer, Vermeulen and De Saeger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A–C) Linearity experiment figures. (A) The metabolite formation of alpha-hydroxy-midazolam (α-OH-MDZ, A) and acetaminophen (B) over time (0–45 min) for different microsomal protein concentrations (0.10–1.0 mg/ml). (C) The AFB1 depletion over time (0–45 min) for different microsomal protein concentrations (0.25–0.50 mg/ml). The horizontal curve (black triangles) represents the 20% metabolite formation threshold. Incubations were performed in triplicate, error bars are displayed. The black arrow indicates the chosen microsomal protein concentration and incubation time.