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. 2022 Apr 28;65(17):11574–11606. doi: 10.1021/acs.jmedchem.2c00252

Figure 1.

Figure 1

Predicted binding mode of 2 (EML108, in sticks, carbon atoms in gray) into PRMT1 (tan) catalytic site (PDB ID: 1OR8).46−48 SAM is depicted in cornflower blue, histone Arg in orchid (for clarity, only the side chain is shown).