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Sensorgrams obtained from the SPR interaction analysis of compounds 12a and 12f–12h (panels a–d, respectively) binding to immobilized PRMT4. Each compound was injected at different concentrations (from 3 to 0.05 μM for 12a and from 640 to 10 nM for 12f–12h) with an association and a dissociation time of 90 s, with a flow rate of 30 μL/min. The equilibrium dissociation constants (KD) were derived from the ratio between kinetic dissociation (koff) and association (kon) constants.
