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Electron density (2Fobs – Fcalc) weighted maps. Compound 12b (a) and compound 12h (b) bound to subunit B of mmPRMT4 (PDB IDs: 7PV6 and 7PUC). PRMT4 is represented as a gray cartoon, and compounds are represented as cornflower blue sticks. Maps are represented as a mesh, with the contouring level set to 1σ. For clarity, N-terminal helices (residues 135–155) of PRMT4 are not shown. E258 and E267 belonging to the double-E loop and H415 of the THW loop are also displayed as sticks.
