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. 2022 Apr 28;65(17):11574–11606. doi: 10.1021/acs.jmedchem.2c00252

Figure 9.

Figure 9

(a) Electron density (2Fobs – Fcalc) weighted maps of compound 12a (represented as cornflower blue sticks) bound to subunit B of mmPRMT6 (represented as a gray cartoon; PDB ID: 7NUD). Maps are represented as a mesh, with the contouring level set to 1σ. For clarity, N-terminal helices (residues 42–56) of mmPRMT6 are not shown. (b) Superimposition (done on protein backbones) of the conformations of compound 12a (yellow or cornflower blue sticks, respectively) when bound to subunit B of mmPRMT4 (represented as a dark gray cartoon) and when bound to mmPRMT6 (represented as a light gray cartoon). For clarity, N-terminal helices of PRMT4 and PRMT6 are not shown.