Scheme 4. Synthesis of Derivatives 12a–12h.
Reagents and conditions: (a) NaH 60% mineral oil, TFAA, dry THF, r.t., 16 h (33–53%); (b) EDC hydrochloride, TEA, DCM, r.t., 18 h (72–81%); (c) DCM/TFA, 1:1, r.t., 2 h (74–80%).
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