Table 3. Affinity and Kinetic Parameters Derived from SPR Experiments.

compound	KD (nM)	kon (1/Ms)	koff (1/s)	τR (s)
12a	663.4	1.67 × 104	0.011	90.9
12b	2300	6.52 × 103	0.015	66.7
12c	359.2	3.49 × 104	0.013	76.9
12d	2800	2.70 × 105	0.760	1.31
12e	603.4	2.58 × 104	0.015	66.7
12f	25.2	2.70 × 106	0.068	14.7
12g	51.7	0.25 × 106	0.013	76.9
12h	75.9	0.21 × 106	0.016	62.5
SAM	9.6	2.90 × 105	0.003	333.3