Table 2. Synergistic Activities of Dilipidated Polymyxin Analogues.
name | ref | FICI | pathogen | antibiotic | hemolytic activitya |
---|---|---|---|---|---|
dilipid polymyxin 1 | (107) | 0.02 | P. aeruginosa | rifampicin | <10% (1 h) |
dilipid polymyxin 2 | (107) | 0.26 | P. aeruginosa | novobiocin | <10% (1 h) |
dilipid polymyxin 5 | (107) | 0.31 | P. aeruginosa | rifampicin | <10% (1 h) |
Non-hemolytic is defined as <10% hemolysis compared to positive control, with incubation times denoted in parentheses.