Table 4. Overview of Synergists Based on Cationic Steroids.

name	ref	FICI	pathogen	antibiotic	hemolytic activitya
squalamine	(224, 226)	0.35b	P. aeruginosa	erythromycin	>10% (10 min)
SM-7	(227)	0.063	K. pneumoniae	rifampicin	<10% (24 h)
Polycationic Cholic Acid Analogues
Ether-linked
I	(229, 230)	0.035	K. pneumoniae	rifampicin	>10% (24 h)
II	(230)	0.029	K. pneumoniae	novobiocin	<10% (24 h)
III	(230)	0.022	K. pneumoniae	novobiocin	>10% (24 h)
IV	(232)	0.13	K. pneumoniae	rifampicin	<10% (24 h)
Ester-Linked
V	(233)	0.057b	E. coli	erythromycin	NR
VI	(233)	0.064b	E. coli	erythromycin	NR
VII	(234)	0.176b	E. coli	erythromycin	<10% (24 h)
Steroid–Peptide Hybrids
VIII	(239)	0.099	E. coli	erythromycin	NR
IX	(239)	0.093	E. coli	erythromycin	NR
X	(239)	0.078	E. coli	erythromycin	NR

^aNon-hemolytic is defined as <10% hemolysis compared to positive control, with incubation times denoted in parentheses; NR denotes no data reported.

^bFICI calculated from MIC values reported in the cited literature references.