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Mechanisms of adaptive resistance to MEK inhibitors. mRNA expression of gene markers of the (a) PI3K/Akt pathway, (b) STAT pathway, and (c) WNT pathway in HCT116 spheroids following cyclic treatments T1 and T2 shown under the x-axis of each graph. Fold change values are relative to nontreated spheroids. Error bars represent standard errors from the mean (n = 2 independent experiments, two replicates/experiment). * denotes p < 0.05 when compared to nontreated spheroids.
