Figure 1.

Distribution map of PXR in human and specific organs of mice (A) Expression profile of the NR1I2 (PXR) gene in human: According to the GTEx database (https://gtexportal.org/home/gene/NR1I2), the NR1I2 (PXR) gene is highly and specifically expressed in small intestine, liver, rectum, and colon, while its expression in other organs/tissues is either low or undetectable. TPM on the vertical axis represents the transcript quantification value, and the horizontal axis represents different tissues (TPM: transcripts per kilobase of exon model per Million mapped reads; tSNE: t-distributed stochastic neighbor embedding); (B) Liver cell scRNA-seq analysis demonstrating that mouse PXR mRNA is highly expressed in the liver, especially in hepatocyte; (C) Large intestine cell scRNA-seq analysis demonstrating that mouse PXR mRNA is expressed in the large intestine, especially in epithelial cell and enterocyte of epithelium.