Table 1.
The agonists of PXR ligand.
| Agonist | Cell line/Species | ||
|---|---|---|---|
| Bile acids | Bile acids (Cross-species) | 12-Ketolithocholic acid; 7-Ketolithocholic acid; 7-Ketodeoxycholic acid; 7,12-Dietolithocholic acid; Cholic acid; Hyodeoxycholic acid; Lithocholicacid; Glycocholic acid; Lithocholic acid-3-sulfate; Glycolithocholic acid; Taurochenodeoxycholic acid; Taurohyodeoxycholicacid; Lithocholic acid acetate; Lithocholicacid acetatemethylester (6) | Cross-species |
| Hormones | Steroids/Steroid hormones | Pregnenolone, Progesterone, Estradiol, Mifepristone, Cyproteroneacetate, Spironolactone, 5β-pregnane-3,20-dione, IncisteroloA5 and A6 (7–9) | HepG2 cell line |
| Glucocorticoid | Corticosterone (7); Dexamethasone (10) | HepG2 cell line | |
| Clinical Drugs | Antifungal agents | Clotrimazole (11) | Zebrafish |
| Antibiotic | Sulfadimidine (8); Triacetyloleandomycin (8); Rifampin; Rifaximin (12) | HepG2 cell line | |
| Drugs for primary biliary cirrhosis | Budesonide (13) | Human | |
| Lipid-lowering drug | SR12813; Atorvastatin; Mevastatin (14) | Human | |
| HMG-CoA reductase inhibitors | Rosuvastatin (15) | HepG2 cell line | |
| Drugs for coronary heart disease | Tan IIA (16) | HepG2 cell line | |
| Antitumor drugs | Paclitaxel/Taxol (17) | LS174T cell line | |
| Antidepressants | Hyperforin (18) | HepG2 cell line | |
| Anticonvulsants | Phenobarbital; Pheytoin; Carbemazepine (18) | HepG2 cell line | |
| Antiarthritics | Sulfinpyrazone (8) | HepG2 cell line | |
| Antihistamines for motion sickness | Meclizine (19) | Human | |
| Metabolites of the antimalarial drug mefloquine | Carboxymethyl fluoroquine (20) | LS174T and HepG2 cell line | |
| Thiazolidinediones | Troglitazone (7) | HepG2 cell line | |
| Anti-HIV drugs | Ritonavir; Efavirenz (21) | hPXR mice | |
| Others | Environmental Factors | Nonylphenol (22); Tributyl citrate (23); Bisphenol A (24) | hPXR mice; LS174T cell line |
| Synthetic (pesticides, chemical products) | Chlordane (7); Patchouli alcohol (25); Prochloraz (26); Aroclor 1260 (27) | HepG2 cell line; hPXR mice; Human | |
| Fragrances | Piperine (28, 29); Anisomycin (30) | hPXR mice; HepG2 cell line | |
| PXR and CAR dual agonists | CITCO (31) | hPXR mice; HepG2 cell line | |
| Cyclohexene-type amides | Nigramide C (32) | hPXR mice | |
| Lead compounds | Tangshenoside II (16, 33) | HepG2 cell line | |
| PXR weak agonists | Resveratrol (34) | mPXR Mice |