NR |
nuclear receptor |
PXR |
pregnane X receptor |
FXR |
farnesoid X receptor |
AF-1 |
activation function 1 |
AF-2 |
activation function 2 |
DBD |
DNA-binding domain |
LBD |
ligand-binding domain |
P |
Phosphorylation |
Ub |
Ubiquitination |
Hsp90 |
heat shock protein 90 |
RXR |
retinoid X receptor |
CAR |
constitutive androstane receptor |
CCRP |
CAR cytoplasmic retention protein |
RXR |
retinoid acid X receptor |
XREM |
xenobiotic response enhancer module |
DR |
direct repeat |
ER |
everted repeat |
IR |
inverted repeat |
MDR1 |
multi-drug resistance gene 1 |
MRP2 |
multi-drug resistance protein 2 |
GST |
glutathione S-transferase |
UGT |
UDP-glucuronosyltransferase |
SULT |
sulfotransferase |
BA |
bile acid |
DME |
drug-metabolizing enzyme |
SMPDL |
sphingomyelin phosphodiesterase acid-like |
OATP |
organic anion transporter |
PEPCK |
phosphoenolpyruvate carboxykinase |
G6Pase |
glucose-6-phosphatase |
HNF4 |
hepatic nuclear factor 4 |
FOXO1 |
forkhead box protein O1 |
FOXA2 |
forkhead box protein A2 |
CREB |
cAMP-response element binding protein |
PGC-1α |
peroxisome proliferator-activated receptor-gamma coactivator-1α |
PCN |
pregnenolone-16α-carbonitrile |
PKA |
activates protein kinase A |
VP-hPXR |
viral protein human PXR |
GLUT2 |
glucose transporter 2 |
SGK2 |
serum/glucocorticoid regulated kinase 2 |
GCK |
glucokinase |
EGCG |
epigallocatechin-3-gallate |
TZD |
thiazolidinediones |
FABP4 |
fatty acid binding protein 4 |
VPA |
valproic acid |
SREBP |
sterol regulatory element-binding protein |
LXR |
liver X receptor |
PPARγ |
peroxisome proliferator-activated receptor γ |
CPT1A |
carnitine palmitoyltransferase 1A |
SCD1 |
stearoyl-CoA desaturease 1 |
HMGCS2 |
3-hydroxy-3-methylglutaryl-coenzyme A synthase 2 |
FGF |
fibroblast growth factor |
HFD |
high fat diet |
NPC1L1 |
Niemann-Pick C1-Like 1 |
MTP |
microsomal triglyceride transfer protein |
ApoA-I |
apolipoprotein A-I |
LCA |
lithocholic acid |
OA |
oleanolic acid |
UA |
ursolic acid |
MK-4 |
menaquinone-4 |
VDR |
vitamin D receptor |
CYP24 |
cytochrome P450 24 |
CYP |
cytochrome P450 |
KIM |
kidney injury molecular |
NAFLD |
non-alcoholic fatty liver Disease |
AS |
atherosclerosis |