Skip to main content
. 2022 Aug 16;13:959902. doi: 10.3389/fendo.2022.959902
NR nuclear receptor
PXR pregnane X receptor
FXR farnesoid X receptor
AF-1 activation function 1
AF-2 activation function 2
DBD DNA-binding domain
LBD ligand-binding domain
P Phosphorylation
Ub Ubiquitination
Hsp90 heat shock protein 90
RXR retinoid X receptor
CAR constitutive androstane receptor
CCRP CAR cytoplasmic retention protein
RXR retinoid acid X receptor
XREM xenobiotic response enhancer module
DR direct repeat
ER everted repeat
IR inverted repeat
MDR1 multi-drug resistance gene 1
MRP2 multi-drug resistance protein 2
GST glutathione S-transferase
UGT UDP-glucuronosyltransferase
SULT sulfotransferase
BA bile acid
DME drug-metabolizing enzyme
SMPDL sphingomyelin phosphodiesterase acid-like
OATP organic anion transporter
PEPCK phosphoenolpyruvate carboxykinase
G6Pase glucose-6-phosphatase
HNF4 hepatic nuclear factor 4
FOXO1 forkhead box protein O1
FOXA2 forkhead box protein A2
CREB cAMP-response element binding protein
PGC-1α peroxisome proliferator-activated receptor-gamma coactivator-1α
PCN pregnenolone-16α-carbonitrile
PKA activates protein kinase A
VP-hPXR viral protein human PXR
GLUT2 glucose transporter 2
SGK2 serum/glucocorticoid regulated kinase 2
GCK glucokinase
EGCG epigallocatechin-3-gallate
TZD thiazolidinediones
FABP4 fatty acid binding protein 4
VPA valproic acid
SREBP sterol regulatory element-binding protein
LXR liver X receptor
PPARγ peroxisome proliferator-activated receptor γ
CPT1A carnitine palmitoyltransferase 1A
SCD1 stearoyl-CoA desaturease 1
HMGCS2 3-hydroxy-3-methylglutaryl-coenzyme A synthase 2
FGF fibroblast growth factor
HFD high fat diet
NPC1L1 Niemann-Pick C1-Like 1
MTP microsomal triglyceride transfer protein
ApoA-I apolipoprotein A-I
LCA lithocholic acid
OA oleanolic acid
UA ursolic acid
MK-4 menaquinone-4
VDR vitamin D receptor
CYP24 cytochrome P450 24
CYP cytochrome P450
KIM kidney injury molecular
NAFLD non-alcoholic fatty liver Disease
AS atherosclerosis